Titration Intelligence for ADHD Care

Reach the right dose in three decisions, not eight weeks.

The ADHD titration platform that turns between-visit silence into a converging signal. Structured daily telemetry, panel triage, and a decision log — embedded in your EHR, sovereign to the prescriber. Pharmacogenomic reference cards layer on when a phenotype is on file — optional, never required.

Telemetry-first · PGx as optional add-on · SMART-on-FHIR ready · CDS, not SaMD
Appetite — 4 of 5 days
Focus trend +1.4
MR
Patient MRD-1001
Atomoxetine 40mg · Day 18
Watch
Dose Symptom Side effect Adherence
18d
In titration
3.2 /5
Avg focus
86%
Adherence

ADHD titration is blind between visits.

Patients keep imperfect journals. Prescribers make dose decisions from memory and one 15-minute check-in. Everyone loses weeks. Some quit.

8weeks

Median duration of an ADHD medication titration cycle — largely driven by check-in cadence, not clinical complexity.

Source: CADDRA guidelines, 2023
30% drop off

Of adults starting ADHD pharmacotherapy discontinue within 90 days — before their dose ever converges.

Source: JAMA Psych, 2019
PGx add-on 2.4x

Higher plasma exposure in CYP2D6 poor metabolizers on atomoxetine — when a phenotype is on file, Titrately surfaces the CPIC card.

CPIC guideline, 2019
PGx add-on 10% of pop.

CYP2D6 poor metabolizer prevalence. Most patients don't know. Many arrive with a prior test result.

PharmGKB clinical annotations
4visits avg

To reach a stable dose. Titrately's design target: two.

Pilot design target
01 — Capture

Under a minute, every day.

Four purpose-built controls. No streaks. No gamification. No engagement mechanics that turn medical adherence into a video game.

Symptom, side-effect, sleep, adherence — the four signals that actually drive titration decisions.
Neurodiverse-safe interface — calm palette, no time pressure, non-punitive gaps.
Auto-stops when the dose stabilises — no perpetual data collection, no perpetual guilt.
Good evening, Alex
Tuesday check-in
How was focus today?
😣 😕 😐 🙂 😁
Any side effects?
None Appetite Sleep Jittery
Took your medication?
On time Late Missed
Save & done
02 — Triage

Only the patients who actually need you today.

Panel-wide triage ranks patients by clinical urgency — tolerability flags, adherence patterns, pending titration decisions. Everyone stable disappears from view.

Rule-based severity engine — not ML magic. Transparent, auditable, adjustable per host.
Sparkline per patient — a 7-day snapshot without opening the chart.
Direct to the record — click a patient, land in your EHR chart with context loaded.
Panel triage
5 need review · 8 stable
Add-on — Pharmacogenomics

The PGx layer, when you have it.

Titrately's core value ships without any genetic testing. Structured telemetry alone compresses titration. When a CYP2D6 or CYP2C19 phenotype is on file, the PK reference cards surface. When it isn't, they don't. Simple as that.

Titrately is not a testing service. We don't run assays, sell kits, or process saliva. We surface published CPIC references against a phenotype you already have.
CPIC-sourced, every card. Guideline name & year on every reference. No proprietary "AI dosing engine." No treatment recommendations.
Boundary text on every response — keeps Titrately on the CDS side of the FDA line. By design.
2D6
CYP2D6 Poor Metabolizer
Atomoxetine · Reference card

Reduced CYP2D6 activity leads to 2.4× higher atomoxetine plasma AUC and prolonged half-life. Onset of therapeutic effect and side-effect windows shift.

CPIC guidance summary
Consider lower starting dose (0.5 mg/kg/day) and extended interval before titrating upward. Recheck tolerability before each step.
PK dosing reference only. Not a treatment recommendation. Clinical decision rests with the prescriber.
How the phenotype gets there

Three ways PGx data enters Titrately.

We don't sample. We don't test. The phenotype comes from wherever the patient's record already lives — or nowhere at all, and the platform still delivers full value.

01
Common today

Already on file

Patient arrives with a prior GeneSight, Genomind, or Tempus panel — or a DTC genotype, or an EHR-imported FHIR observation. Prescriber enters the phenotype at episode start. Cards appear.

No sampling · No delay
02
When titration stalls

Ordered by the prescriber

Clinical suspicion of PM/UM. First-line med failed. Preemptive testing at intake. Buccal swab or blood draw. Results in 3–7 days, ~$150–$300 (often reimbursed for psychiatric indications).

Titrately doesn't order · Clinician does
03
Majority path

Not needed at all

Most titrations don't require PGx to succeed. The timeline, triage, and decision log deliver full value without any phenotype data. Cards simply don't fire — nothing else changes.

Full platform value · No PGx required
For EHR & Telehealth Platforms

One integration. Every prescriber gets titration intelligence.

Titrately embeds inside your platform via SMART-on-FHIR & OAuth 2.0. Your prescribers never leave your workflow. Your data-residency and RLS-by-host_id boundaries hold. Your brand stays central. We are the module — you are the platform.

Talk to integration
The Regulatory Line

CDS, not SaMD. By design.

Titrately stays on the clinical decision support side of the FDA line. Not because we're timid — because it's the honest position for a reference engine.

01

Never prescribe

No output says "reduce to X" or "switch to Y." Only: literature reference for this phenotype and this drug.

02

Human-in-the-loop

Every observation is framed as telemetry ready for review or reference material for clinical judgment.

03

Attribute the source

Every PK card links to the published CPIC guideline or PharmGKB annotation. Verify independently, in one click.

04

Boundary on every response

"PK reference only. Not a treatment recommendation. Clinical decision rests with the prescriber." Every card. Every time.

From the field
Between visits, my ADHD patients live in a fog and I live in an inbox. Titrately is the first tool that lets us both meet at a signal, not a story.
DR
Dr Rania A., MD, MPH
Attending Psychiatrist · Advisor
For EHR / Telehealth Platforms

Embed titration intelligence in your product.

Prescriber sovereignty preserved. RLS-by-host_id. SMART-on-FHIR. Your brand stays central. Our engine stays reference-only. Ask about the pilot programme.

For Specialty Clinics

Run Titrately in your practice.

Self-hosted or fully-managed instance. Bring your own EHR or use our lightweight cockpit. HIPAA-ready. Priced per active titration, not per seat.